Question 1

The primary response is characterized by:

Accepted Answer

A)   the recognition of antigens by naïve B cells.
B)   the recognition of antigens by memory B cells.
C)   the production of large amounts of IgG.
D)   a very short lag period.
E)   a long duration of high titer.F) B) and C)
G) B) and E)

Question 2

Bence-Jones proteins are identical to:

Accepted Answer

A)   secretory IgA.
B)   heavy chains.
C)   light chains.
D)   IgG molecules.E) A) and B)
F) All of the above

Question 3

Which region of the immunoglobulin molecule can bind antigen?

Accepted Answer

A)   Fab
B)   CL
C)   CH
D)   Hinge regionE) B) and D)
F) A) and B)

Question 4

Identify the characteristic that best describes IgE.

Accepted Answer

A)   Fixes complement
B)   Binds to mast cells
C)   Found on mucosal surfaces
D)   Participates in agglutination reactionsE) B) and C)
F) A) and D)

Question 5

Select the statement about secondary response to an antigen that is true.

Accepted Answer

A)   Equal amounts of IgM and IgG are made.
B)   IgG is increased 100-fold to 1,000-fold.
C)   IgM is increased 100-fold.
D)   The lag time is the same as the primary response.E) B) and C)
F) A) and D)

Question 6

Immunoglobulins IgG,IgM,IgA,and IgD represent:

Accepted Answer

A)   isotypes.
B)   allotypes.
C)   idiotypes.
D)   heterotypes.E) C) and D)
F) B) and C)

Question 7

IgG subclasses differ from one another in the number and position of:

Accepted Answer

A)   heavy chain domains.
B)   antigen binding sites.
C)   light chains.
D)   disulfide bonds.E) B) and D)
F) B) and C)

Question 8

IgA in secretions has a valence of:

Accepted Answer

A)   1.
B)   2.
C)   4.
D)   10.E) A) and D)
F) A) and C)

Question 9

Identify the correct pairing of an immunoglobulin and its property.

Accepted Answer

A)   IgA: crosses the placenta
B)   IgG: most abundant in serum
C)   IgM: immunoglobulin produced by a T cell
D)   IgE: major immunoglobulin of secondary responseE) C) and D)
F) A) and B)

Question 10

Which immunoglobulin activates the classical complement pathway?

Accepted Answer

A)   IgD
B)   IgM
C)   IgA
D)   IgEE) A) and B)
F) A) and C)

Question 11

Which antibody is found mainly as a dimer in mucosal secretions?

Accepted Answer

A)   IgA
B)   IgD
C)   IgE
D)   IgGE) C) and D)
F) A) and D)

Question 12

Which immunoglobulin appears in the highest titer in the secondary response?

Accepted Answer

A)   IgG
B)   IgA
C)   IgM
D)   IgDE) All of the above
F) A) and B)

Question 13

The ability of an antibody to opsonize is located in which region?

Accepted Answer

A)   F(ab) 2
B)   Fc
C)   VL + VC
D)   HypervariableE) C) and D)
F) B) and C)

Question 14

Variations in immunoglobulin structure that occur because of the use of different constant region domains are known as:

Accepted Answer

A)   allotypes.
B)   idiotypes.
C)   isotypes.
D)   autotypes.E) None of the above
F) A) and B)

Question 15

Which is characteristic of IgG?

Accepted Answer

A)   First class of antibody to appear
B)   Found mainly in secretions
C)   The least abundant antibody in serum
D)   Provides immunity for the newbornE) A) and C)
F) None of the above

Question 16

What products are the result of papain being used to cleave antibody molecules?

Accepted Answer

A)   Two Fab fragments and one Fc portion
B)   Two L chains and two H chains
C)   VL, CL, VH, and CH
D)   One F(ab) 2 and Fc' portionsE) None of the above
F) B) and C)

Question 17

Of all IgG subclasses,IgG3 has the largest hinge region,making it:

Accepted Answer

A)   the only subclass capable of crossing the placenta.
B)   the subclass with the highest number of antigen binding sites.
C)   the most efficient subclass for activating complement.
D)   incapable of opsonization.E) B) and C)
F) A) and D)

Question 18

Identify the true statement about the anamnestic response versus the primary response.

Accepted Answer

A)   The primary response has a long lag phase; the anamnestic response has a short lag phase.
B)   The primary response has a short lag phase; the anamnestic response has a long lag phase.
C)   the primary response involves a rapid increase in antibody titer, whereas the anamnestic response involves a rapid decrease in antibody titer.
D)   The primary response involves predominantly an increase in IgG antibodies, whereas the anamnestic response involves predominantly an increase in IgM antibodies.E) A) and B)
F) B) and C)

Question 19

Immunoglobulins are grouped into classes on the basis of similarities in:

Accepted Answer

A)   light chains.
B)   heavy chains.
C)   antigen binding sites.
D)   disulfide bonds.E) B) and D)
F) A) and B)

Question 20

Which immunoglobulin causes allergic reactions as a result of release of histamine from mast cells?

Accepted Answer

A)   IgA
B)   IgE
C)   IgD
D)   IgME) B) and C)
F) B) and D)

Exam 5: Antibody Structure and Function

IgG subclasses differ from one another in the number and position of:

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Select the statement about secondary response to an antigen that is true.

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Which region of the immunoglobulin molecule can bind antigen?

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Immunoglobulins are grouped into classes on the basis of similarities in:

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Variations in immunoglobulin structure that occur because of the use of different constant region domains are known as:

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Identify the true statement about the anamnestic response versus the primary response.

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IgA in secretions has a valence of:

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Of all IgG subclasses,IgG3 has the largest hinge region,making it:

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Which is characteristic of IgG?

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What products are the result of papain being used to cleave antibody molecules?

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The primary response is characterized by:

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The ability of an antibody to opsonize is located in which region?

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Identify the characteristic that best describes IgE.

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Which immunoglobulin activates the classical complement pathway?

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Which immunoglobulin causes allergic reactions as a result of release of histamine from mast cells?

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Bence-Jones proteins are identical to:

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Identify the correct pairing of an immunoglobulin and its property.

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Immunoglobulins IgG,IgM,IgA,and IgD represent:

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Which antibody is found mainly as a dimer in mucosal secretions?

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Which immunoglobulin appears in the highest titer in the secondary response?

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