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The most likely explanation for the fact that the human genome consists of 3.2 billion bases,and encodes about 20,325 proteins,is that


A) all of the genome encodes protein.
B) the genome includes many copies of the instructions for each type of protein.
C) amino acids encode DNA sequences.
D) much of the genome does not encode protein.
E) each protein is encoded by about 160,000 DNA bases.

F) A) and E)
G) B) and C)

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A mutation that adds one or two bases to a gene disrupts the


A) replicating frame.
B) intron index.
C) genetic code.
D) reading frame.
E) mutational profile.

F) B) and E)
G) A) and B)

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Which choice is the correct sequence from smallest to largest?


A) amino acid, peptide, polypeptide, protein
B) protein, polypeptide, peptide, amino acid
C) genome, chromosome, gene, DNA
D) amino acid, DNA, peptide, gene
E) peptide, polypeptide, amino acid, protein

F) A) and C)
G) C) and D)

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A signal sequence


A) directs RNA nucleotides to a particular gene.
B) attracts tRNAs to an mRNA.
C) is the first part of a protein's amino acid sequence that helps to direct it to a certain part of the cell.
D) is a coding codon that mutates into a stop codon.
E) is part of proteins that are synthesized on free ribosomes.

F) B) and E)
G) A) and E)

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The scientists who identified a set of coordinately regulated genes,called an operon,responsible for lactose metabolism in E.coli were


A) Watson and Crick.
B) Meselson and Stahl.
C) Jacob and Monod.
D) Hershey and Chase.
E) Linus and Pauling.

F) A) and E)
G) C) and D)

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In a bacterial cell,the three genes of the lactose operon are


A) expressed continuously.
B) expressed only when lactose is absent.
C) expressed when lactose synthesis is required.
D) expressed only in the presence of lactose.
E) never expressed, because they are pseudogenes.

F) A) and B)
G) C) and E)

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To express a gene,DNA is first transcribed into a corresponding strand of


A) mtDNA.
B) rRNA.
C) mRNA.
D) tRNA.
E) siRNA.

F) C) and E)
G) A) and B)

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If part of a DNA template is the sequence GTTAGTCTGTGGGCT,then the mRNA transcribed from it is


A) GTTAGTCTGTGGGCT.
B) CAATCAGACACCCGA.
C) CAAUCAGACACCCGA.
D) gln-ser-asp-thr-arg.
E) val-ser-leu-trp-ala.

F) D) and E)
G) C) and D)

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In addition to encoding protein,DNA sequences in the human genome


A) encode fats.
B) control the sequences that encode proteins.
C) encode carbohydrates.
D) encode themselves.
E) rapidly interconvert to RNA.

F) B) and C)
G) A) and E)

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Which codons are synonymous?


A) CAC and CAG
B) CAC and CAU
C) ACA and AGC
D) UCC and GAC
E) CCC and AAA

F) All of the above
G) A) and B)

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Ribose is an important component of RNA because


A) it is less stable than deoxyribose, which enables RNA to function as a short-term carrier of genetic information.
B) it is more stable than deoxyribose, which enables RNA to function as a short-term carrier of genetic information.
C) it is less stable than deoxyribose, which enables RNA to function as a long-term carrier of genetic information.
D) it is more stable than deoxyribose, which enables RNA to function as a long-term carrier of genetic information.
E) it is as stable as deoxyribose, which makes RNA and DNA functionally equivalent.

F) C) and E)
G) B) and C)

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Part of a DNA template of sequence GTTAGTCTGTGGGCT corresponds to the amino acid sequence


A) GTTAGTCTGTGGGCT.
B) CAATCAGACACCCGA.
C) CAAUCAGACACCCGA.
D) gln-ser-asp-thr-arg.
E) val-ser-leu-trp-ala.

F) B) and D)
G) None of the above

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Diseases that are caused by protein misfolding include


A) tuberculosis, malaria, and AIDS.
B) river blindness, leprosy, and African sleeping sickness.
C) cystic fibrosis, Huntington disease, and sickle cell disease.
D) acne, restless legs syndrome, and insomnia.
E) cancer, pulmonary embolism, and hypertension.

F) B) and D)
G) A) and B)

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Place the types of RNA molecules in correct size order,from smallest to largest.


A) mRNA, tRNA, rRNA
B) aRNA, bRNA, cRNA
C) tRNA, rRNA, mRNA
D) tDNA, rDNA, mDNA
E) proline, glycine, tyrosine

F) B) and D)
G) None of the above

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The DNA template ATGCGTTA is transcribed into an RNA strand with the sequence


A) TACGCAAT.
B) UAACGCAU.
C) UACGCAAU.
D) AUGCGAAU.
E) AUGCGUUA.

F) A) and E)
G) A) and D)

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During transcription


A) protein is synthesized from DNA.
B) DNA is replicated.
C) RNA is synthesized from protein.
D) RNA is synthesized from DNA.
E) protein is synthesized from amino acids.

F) None of the above
G) A) and D)

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There are __ different sequences of codons possible in the genetic code.


A) 3
B) 4
C) 16
D) 64
E) 46

F) A) and D)
G) C) and D)

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RNA differs from DNA in that


A) most of it is single-stranded.
B) it is usually double-stranded.
C) it has thymine instead of uracil.
D) it has deoxyribose instead of ribose.
E) it encodes information but has no other functions.

F) A) and C)
G) A) and E)

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___ tRNAs are required to translate the DNA template sequence GTTAGTCTGTGGGCT into amino acids.


A) Two
B) Three
C) Four
D) Twenty
E) Sixty-four

F) None of the above
G) C) and E)

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The linear order of amino acids in a polypeptide is the _______ structure of a protein.


A) primary
B) secondary
C) tertiary
D) quaternary
E) chaperone

F) C) and D)
G) B) and D)

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